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[17] The ratio of reduced glutathione to oxidized glutathione within cells is a measure of cellular oxidative stress [18] [11] where increased GSSG-to-GSH ratio is indicative of greater oxidative stress
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As a critical organelle in eukaryotic cells, mitochondria not only serve as the central hub for energy metabolism but also play a pivotal role in regulating inflammation and cell apoptosis
In conclusion, exploration of the pathophysiological and pharmacological roles of H 2 S and of persulfide/polysulfide formation in biological systems has been hampered by the lack of methods to quantify bulk changes
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