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Both ROS and RNS are continuously generated in vivo as part of normal cellular metabolism and at physiological levels, they serve important signalling and regulatory functions
In particular, GLP1-RA counteract the action of angiotensin II (ANG II) inhibiting its synthesis, increasing the inactivation of its circulating form and contrasting its action on target tissue like glomerular endothelial cells and cardiomyocytes
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Whether the drugs can be used to prevent or treat dementia is also being studied, with mixed results
Presented for research literature review only Kang TS et al
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