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There are concerns about the development of diabetes and metabolic syndrome with long-term use

2011 Aug;28(8):1857-65

It is particularly useful if you are specifically looking for respiratory support

Pak J Pharm Sci 31(5):19511957 Lubrich C, Giesler P, Kipp M (2022) Motor behavioral deficits in the cuprizone model: validity of the rotarod test paradigm