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More recently, tirzepatide, a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist, has been shown in a randomized controlled trial to achieve greater weight reduction than semaglutide (13)
Conversely, TFL concentrates exclusively on fertility loss
It was approved for weight loss by the FDA in 2021
Nevertheless, in vitro exendin-phe1-induced insulin release exceeded that of exendin-4 in the low nanomolar range (Fig
However, it does not yet permit commercialization, as patent protections and regulatory exclusivities tied to the reference product remain in place
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