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Another study also demonstrated that lactate, produced under hypoxic conditions in colorectal cancer (CRC), promotes the lactylation of H3K18, which in turn induces the transcription of autophagy enhancer protein RUBCNL, then promotes the maturation of autophagosomes, and mediates the recruitment of class III phosphatidylinositol 3-kinase(PI3K) complexes, thereby promoting tumor proliferation and mediating tumor resistance to bevacizumab [33]
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In the control group, the pH was neutral in the esophagus, but acidic in the stomach, weakly acidic in both the duodenum and jejunum, and finally neutral in the ileum (Fig
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