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44 As an add-on therapy in 1864 T2D adults uncontrolled with metformin alone or with sulfonylurea (PIONEER-3), 7 mg and 14 mg of once-daily oral semaglutide were superior to 100 mg of once-daily sitagliptin at 26 weeks, in terms of both HbA1c and weight reductions (HbA1c reduction of 1.0 and 1.3% vs 0.8%, respectively
Most gastrointestinal side effects peak during weeks 2-8 of treatment, then gradually improve through week 12 as your digestive system recalibrates
Remaining Questions and Future Directions Despite promising findings, data for other ARDs remain limited
Prior Presentation: This work was presented in part as a poster at the Endocrine Society (ENDO) Annual Meeting held July 1215, 2025, in San Francisco, CA, USA
Like all medicines, Wegovy can cause side effects, though serious reactions are rare
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