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Risk of bias was rated low for the RCT in most domains [14]

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The CSF flow, as here quantified, is thus employed as a proxy for CSF secretion, and has repeatedly been demonstrated to be affected similarly to CSF secretion rates obtained by the ventriculo-cisternal perfusion assay by different modulators (activator/inhibitors) [36, 37, 46, 47]

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While off-label prescribing is legally permitted under specialist supervision with informed consent, it is not routinely commissioned for Parkinson's disease in the NHS