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Emerging incretin- and multi-agonist-based treatments: the continued refinement and continuous expansion of a potent therapeutic armamentarium for cardio-kidney-liver-metabolic diseases and beyond

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GLP-1 RAs are effective and safe treatments for controlling blood sugar levels and reducing body weight, and evidence from large clinical trials also suggests that GLP-1 RAs may be renoprotective

Furthermore, high-dose L-carnitine significantly lowered the incidence of ventricular arrhythmias following myocardial infarction (Lango et al

Induction of these chaperones represents an adaptive stress response that protects cardiomyocytes by stabilizing the contractile apparatus and preserving sarcomeric organization during ischemic injury