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36 Pegbelfermin (BMS-986036), a PEGylated human FGF21 analog, has been suggested to ameliorate metabolic parameters and liver fibrosis in obese patients with T2DM

44, 77 Methymalonic acid, a metabolite of PPA, results in abnormal mitochondrial morphology, 78 tissue specific ETC dysfunction, 79 inhibition of the complex I and II function when interacting with complex III in the brain 80 and reductions in reduced glutathione, 78 similar to the patient cohort presented and the PPA animal model

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Biochemical and biophysical research communications , 280 (1), 132138

Its natural to gradually lose collagen and elastin with age, though certain lifestyle habits such as smoking and excessive sun exposure can increase the rate of loss