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Contrave treated participants saw 5% weight loss compared to placebo at week 28 (55.6%
According to another analysis [34], the published results, as a rule, show an improvement in some brain parameters (for example, hippocampal connectivity, glucose metabolism in the brain, hippocampal activation according to functional magnetic resonance imaging), but could not demonstrate a strong correlation with cognitive indicators
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Semaglutide (Wegovy, Ozempic) is the second most effective at 10-15% average weight loss
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