5 Hypoxic stress at high altitude can trigger a series of physiological responses across multiple organ systems, especially the brain (increased cerebral blood flow), pulmonary system (increased ventilation and pulmonary vascular remodeling), cardiovascular system (increased heart rate, cardiac output, and systemic blood pressure), renal system (increased bicarbonate excretion and erythropoietin (EPO) secretion), and hematologic system (increased red cell mass, hemoglobin (Hb) concentration, and hematocrit (Hct)), thereby increasing oxygen content and delivery in the body
Both flagged some examples as posing potential legal risks, under statutes that limit the claims health care providers can make about drugs that are not FDA-approved
Neurons depend heavily on oxidative phosphorylation and calcium buffering, whereas astrocytes can increase glycolysis and shuttle lactate [11, 12]
Dopamine- or L-DOPA-induced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinsons disease
On JL, Ghaderi S, Rittmann C, Hoffmann G, Gier F, Woloschin V, et al