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Theres some promise when it comes to using berberine as a supplement, but its important to talk to your healthcare provider beforehand
That third receptor is the reason it is called a triple agonist
KFF.org
Achieving site-specific transcranial drug delivery to closed-skull TBI patients may be more difficult than the authors imply: the subarachnoid space filled with circulating cerebrospinal fluid (CSF) is about 3-4 mm deep in humans (3), more than an order of magnitude deeper than in mice, permitting CSF to quickly remove drug molecules from a targeted cortical site
This ability allows it to directly target the central nervous system, where it exerts its effects by alleviating mitochondrial dysfunction, which is often observed in individuals with ASD
