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Clinical Pharmacokinetics, 58 (5), 651659

According to the Endocrine Society's 2024 clinical practice guideline on pharmacological management of obesity, tirzepatide is recommended as a first-line pharmacotherapy option for adults with obesity, with the Society explicitly noting that step therapy requirements "may delay access to the most effective available agents." This guideline gives prescribers evidence-based ammunition when challenging step therapy mandates

Demonstrating that tirzepatide offers superior glycemic control and weight reduction compared to other covered GLP-1 agents strengthens the medical necessity argument

She encourages researchers to look at what the clinical data say and carefully design their studies accordingly