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Beyond psoriasis: a platform for inflammatory disease PEPITEM and its components are part of a wider research programme exploring their use in chronic inflammatory conditions such as rheumatoid arthritis, diabetes, and lupus
The strongest published finding is from the foundational Biochemical Pharmacology study by Neelakantan et al.: in diet-induced obese mice, daily 5-Amino-1MQ administration produced reductions in body weight, white adipose tissue mass, and adipocyte size without any significant change in food intake
If reducing intake seems beneficial, patients should decrease consumption slowly over one to two weeksfor example, by mixing regular and decaffeinated coffee or reducing the number of daily cups incrementally
Whether you are dealing with a stall in your progress or just starting out, a science-backed approach is the most sustainable way to reach your goals
Ren et al., 2025)
