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18 The hypothesis of this study is that the BBB is disrupted during HE and that circulating TGF 1 contributes to increased vascular permeability via the upregulation of MMP9 and disruption of tight junction proteins
One-quarter tablet (200 micrograms) Actifolate One-quarter tablet Intrinsic B12/folate (200 mcg of folate as folic acid, 5-methyl tetrahydrofolate, and 5-formyl tetrahydrofolate (folinic acid or leucovorin), 125 mcg of vitamin B12 as cyanocobalamin, 22.5 mg of calcium, 17.25 mg of phosphorus, and 5 mg of intrinsic factor)
Transcriptional regulation by hypoxia inducible factors
improved neurobehavioral outcomes
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