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Hypoxia also leads to suppression of local immune cell function resulting in an immunosuppressive microenvironment (Stritzker et al., 2010
Research using LPS-stimulated macrophage models and UV-challenged skin cell lines has documented percentage reductions in IL-6 and TNF-alpha secretion following GHK-Cu treatment, with some studies reporting reductions in the 30 to 60% range compared to untreated challenge controls
Biosci Biotechnol Biochem 81(11):22122215
A 2012 study by Arakawa and colleagues of thyroid patients with Hashimotos and Graves, found that polymorphisms that is, gene variations that may lead to the abnormal expressions were as common in autoimmune thyroid disease as they were in the normal population
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