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The caloric reduction from appetite suppression does the heavy lifting for weight loss
![glp-1/gip vs tirzepatide Structures of (a) GLP-1, (b) GIP and (c) [19, 88, 90] Retatrutide vs Tirzepatide for weight](https://anglopeptides.ca/wp-content/uploads/2026/07/img-02-hero-semaglutide-vs-tirzepatide.png)
Summary: Retatrutide is an investigational triple receptor agonist (GLP-1, GIP, and glucagon) that, based on Phase 2 trial data, produces significant appetite suppression and progressive weight loss, alongside gastrointestinal side effects that are most prominent during dose escalation
![glp-1/gip vs tirzepatide Structures of (a) GLP-1, (b) GIP and (c) [19, 88, 90] Retatrutide vs Tirzepatide for weight](https://greenreliefmd.com/wp-content/uploads/2026/03/how-does-tirzepatide-work-1-1024x512.webp)
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![glp-1/gip vs tirzepatide Structures of (a) GLP-1, (b) GIP and (c) [19, 88, 90] Retatrutide vs Tirzepatide for weight](https://www.researchgate.net/publication/397852225/figure/fig2/AS:11431281739060009@1763794678108/Mechanisms-of-action-of-GLP-1-RA-and-GLP-1-GIP-dual-agonists-improve-decrease.jpg)
Regular monitoring with your doctor is recommended if you stay on it long term
![glp-1/gip vs tirzepatide Structures of (a) GLP-1, (b) GIP and (c) [19, 88, 90] Retatrutide vs Tirzepatide for weight](https://geneva-med.com/wp-content/uploads/2025/09/shutterstock_2165413479-scaled.jpg)
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