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The predominantly alpha-helical C-terminal domain is involved with the binding of hydrophobic substrates (such as hydrophobic portions of xenobiotics)
International Journal of Sports Medicine, 17(5), 320324
[152] suggest that modulation of fatty acid oxidation may regulate the amount of energy available for protein synthesis in osteoblasts
Another recent published work demonstrated that reduced NRF2 expression is responsible for the decline of neural stem/progenitor cell (NSPC) function, as it is found that NRF2 expression was suppressed in the aged NSPC, and overexpression of NRF2 in those old cells could render them to a similar state as the young NSPCs, by showing increasing cell survival and regeneration [126]
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