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The key insulinotropic actions of GLP-1 via the class B1 G-protein-coupled receptor (GPCR) are exerted by cyclic adenosine monophosphate (cAMP) formation, which, in conjunction with increased Ca 2+ levels, promotes exocytosis of insulin-containing vesicles [39]
Page SC, Sripathy SR, Farinelli F, Ye Z, Wang Y, Hiler DJ, et al
This enhanced effectiveness is related to the medicines'capacity to influence both peripheral and central pathways that govern energy balance
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