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An in vitro study using GnRH neurons of adult male mice demonstrated that both GLP-1 and Ex4 might excite GnRH neurons, either directly or indirectly by modulating the nitric oxide (NO) and endocannabinoid pathways that control the presynaptic excitatory GABA-ergic inputs to GnRH neurons [36]

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PLoS ONE 14 , e0209995 (2019)

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The 10-fold increase of GLR1 activity in CO23FLC may contribute to the high level of GSH along with the increased GSH1 activity