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These SCFAs bind to L-cell receptors, stimulating the release of GLP-1 and promoting glucose metabolism

After millions of Rx, registry and real world data show no signal, yet the warning persists and dissuades many from a useful Rx #T2D gut.bmj.com/content/early/ Liraglutide, the first long acting GLP-1RA was approved 12 years ago with a black box warning for MTC based on rodent data

However, most large-scale clinical trials of semaglutide (including the STEP trials for weight loss) used the standard once-weekly schedule, so direct evidence comparing weekly versus twice-weekly dosing remains limited in the published literature

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