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10.1016/j.phrs.2022.106367 44 LyuX.YanK.WangX.XuH.GuoX.ZhuH.et al (2022)
These include pancreatitis, gastroparesis, gallbladder and biliary disease, and, in select cases, acute kidney injury related to dehydration
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In simpler terms, tirzepatide keeps the receptor at the cell surface longer but may affect its internal signaling differently
216,217 Exendin-4 was also demonstrated to increase lysosomal function in another study, whereby autophagosome clearance in a rat model of tacrolimus-induced diabetes was increased, promoting cell survival given that autophagosome accumulation causes intracellular damage
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