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Retatrutide is a triple agonist (GLP-1 + GIP + glucagon), tirzepatide is a dual agonist (GLP-1 + GIP), and semaglutide is a single agonist (GLP-1)
Despite the evolutionary pressure to avoid the high expression of proteins with large hydrophobic surfaces, the brain paradoxically expresses such proteins at elevated levels 40
Adequate water intake softens stools, facilitating bowel movements despite the medication's effects on digestion
Given all these factors, many in the medical community urge extreme caution
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