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Above 30C, the degradation rate accelerates beyond what the in-use window assumes

The concurrent glucagon receptor activation makes unsupervised dose escalation more clinically risky than with pure GLP-1 agents

Indeed, an optimized Fer-1 molecule with an improved ADME (absorption, distribution, metabolism, and excretion) profile is expected to move into preclinic and clinic trials [115]

Increased injection frequency at unchanged doses could amplify nausea, vomiting, constipation, abdominal pain, and injection-site reactions

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