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In my opinion, this is what separates successful natural product programs from the ones that stay behind: Context-rich screening: testing in disease-relevant cell models reveals therapeutic potential that biochemical assays miss Multi-parameter profiling: simultaneous readouts for efficacy, toxicity, and mechanism accelerate go/no-go decisions Reproducibility at scale: validated protocols that work whether you are testing 10 compounds or 10,000 Bridge to clinic: immortalized primary cells and iPSC models that predict patient response better than traditional cell lines or biochemical assays The teams that win in phytopharma don't just screen compounds
[35,36] Berberine also seems to have favorable effects on blood cholesterol and triglycerides, which is to be expected since AMPK promotes fat uptake as much as glucose uptake
Note: BMI is one factor
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