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[5] That breadth of gene regulation is striking, though it also means most claimed effects remain at the in vitro stage with limited in vivo confirmation in humans
The incretins carry the stronger clinical record
That was Male 1.0
However, even a 50% reduction in worm burden would decrease the human health problems caused by schistosomiasis, and a combination of auranofin (or another TGR inhibitor) with an agent that works by a different mechanism might be more effective and would also reduce the chances of the parasite developing drug resistance
This effect could be attributed to the inclusion of positively charged BER within the lipid bilayer, enabling interactions with negatively charged phospholipids
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