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A single session is reasonable for acute goals like hydration
Sue CM, Bruno C, Andreu AL, Cargan A, Mendell JR, Tsao C-Y, et al
Baseline testing was done one week prior to intraventricular infusion of MT-II or vehicle control, and repeat testing was performed on day nine of infusion
To further validate the above discovery, the authors designed two structurally similar fentanyl derivatives FBD1 (partial agonist) and FBD3 (full agonist), with the aim to obtain OR agonists with reduced/abolished -arrestin signaling but relatively intact G protein activity (Figure 6a)
Suzuki et al., 1986
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