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Studies suggest it can block the NF-B pathway and reduce inflammatory cytokines like TNF- and IL-6 without causing skin darkening, making it a potentially safe option for systemic use

7.4.3 Combination therapies The modest biomarker effects observed in the EVOKE trials suggest that semaglutide interacts with central pathologic processes

The question of whether Tirzepatide is superior to Semaglutide depends on individual patient needs and preferences

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