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The role of vitamin B12 and 5-methyl-THF in the conversion of homocysteine to methionine also can have a significant impact on the ability of cells to regenerate the needed active pool of THF derivatives and as such represents the physiologically most significant reaction involving folate

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Metformin is a longstanding treatment for type 2 diabetes

Or it could be that the drugs wont work well enough for these conditions

Improvement in lipid profile (reduction in triglycerides and LDL cholesterol)