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By preventing the oxidation of BH4 by rampant free radicals, Vitamin C ensures that the endothelium can produce adequate nitric oxide
Chronic elevation of these free radicals will deplete GSH/GSSG redox/antioxidant capacity, allowing unopposed free-radical generation and a self-perpetuating cycle, leading to chronic oxidative stress and damage
Cardiac nNOS is localized to the sarcoplasmic reticulum (SR) where it is involved in the Ca 2+ handling processes of cardiac excitation-contraction coupling
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