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1 Introduction Diseases of the retina are a primary factor in causing permanent blindness and vision loss, impacting millions of individuals globally ( Ferroptosis is a programmed death modality of non-apoptotic cells that relies on the accumulation of iron in cells, resulting in an increase in the toxic lipid peroxide reactive oxygen species (ROS) ( Iron is essential for retinal metabolism, but an excess of ferrous iron causes oxidative stress, which is one of the main mechanisms for the occurrence of ferroptosis ( 3+ ) that bind to transferrin (TF) are transported into cells via transferrin receptor (TFRC)
