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An additional third of the EDTA-treated plasma was flash frozen on dry ice and stored at 80 o C without prior deproteinization but was deproteinized upon thawing

1 Collectively, tumor-intrinsic mechanisms, spanning genetic mutation, epigenetic reprogramming, immune checkpoint activation, and cellular plasticity, converge to create a highly adaptable, treatment-refractory phenotype

Important gaps include independent replication, validated potency methods, long-term toxicology, interaction data, broader population research, and adequately powered confirmatory trials

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Hence, its crucial that the therapy is administered by a qualified healthcare professional who can monitor for these risks