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The hippocampus has long been a pivotal focus in epilepsy research and observations have shown a reduction in the size of hippocampi in epileptic patients brains (Pitknen and Sutula, 2002)
Boxed warning suicidal thoughts and behaviors: Bupropion, one of the two active ingredients in Contrave, carries an FDA boxed warning about increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults (under 25) taking antidepressants
It is not yet FDA-approved but has shown remarkable weight loss results in phase 2 trials, with participants losing up to 24.2% of body weight at the highest dose over 48 weeks
Additional studies have explored activation of focal adhesion kinase (FAK) and paxillin pathways in fibroblasts, which are involved in cellular migration, extracellular matrix interactions, and structural tissue dynamics [2]
Given the plethora of publications on either diabetes or depression or the cooccurrence of these conditions, a synthesis of the published literature on the occurrence of depression and diabetes is needed
