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Clinical investigations have principally evaluated fasting plasma glucose, glycated hemoglobin (HbA1c), fasting insulin, and the homeostatic model assessment of insulin resistance (HOMA-IR) as primary metabolic end-points
Proc Natl Acad Sci U S A 117(51):3237032379
In one study, participants took 500 or 1000 mg per day
S.WangX.HuoL.SunN.et al (2023b)
This depletion correlates directly with elevated ventricular lactate levels, providing concrete biological evidence that the brains of these patients are trapped in a state of high oxidative stress and inefficient anaerobic metabolism
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