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The STEP trials showed semaglutide to be superior to liraglutide in terms of weight loss
This has prevented it from being effectively developed as a treatment
In clinical trials, diarrhea is a common side effect, occurring in approximately 30% of patients taking Wegovy (semaglutide 2.4 mg) and 19-23% of patients taking Zepbound (tirzepatide), according to FDA prescribing information
Am J Transl Res (2019) 11(8):465066
The catch is that most of these medications are peptides chains of amino acids that your digestive system would break down before they ever reached your bloodstream
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