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[2] For subclinical hypothyroidism (elevated TSH with normal free T4), treatment should be considered if TSH 10 mIU/L on two tests 3 months apart, or as a time-limited trial in symptomatic adults, especially if TPO-antibody positive
Peacock, B.N
The role of GIP receptor in the CNS for the pathogenesis of obesity
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Two randomized controlled trials in women with hypothalamic amenorrhea have shown conflicting results: one indicated an increase in osteocalcin and N-telopeptides of type 1 collagen (NTX) but no change in BMD [102], while the other revealed increased spine BMD in lean women with hypoleptinemia [101, 103, 104]
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