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NICE NG28 recommends considering an SGLT2 inhibitor as the preferred option in adults with type 2 diabetes and chronic kidney disease or heart failure, unless contraindicated or not tolerated
Antimicrob Agents Chemother 1989;33:474-8
Tirzepatide is a glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for the treatment of type 2 diabetes mellitus and chronic weight management
In the STEP trials, semaglutide 2.4 mg weekly showed average weight reductions of 1215% of body weight over 68 weeks, whilst in the SCALE trials, liraglutide 3 mg daily typically produced 58% weight loss
The compound is commonly investigated in biochemical research for its interaction with signalling mechanisms and peptide-mediated regulatory processes
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