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Description

Oral dosing keeps plasma ascorbate below roughly 220 micromoles per liter (mol/L), whereas controlled IV infusion can safely **generate** pharmacologic concentrations of 2530 millimoles per liter (mmol/L)a finding documented by Mark Levines National Institutes of Health group in Vitamin C pharmacokinetics: implications for oral and intravenous use (Padayatty and colleagues, Annals of Internal Medicine, 2004)

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Patients are randomly assigned to treatment or placebo groups, and neither patients nor evaluators know who received which (double-blind)

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