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Ebselen (2-phenyl-1,2-benzoisoselenazol-3(2H)-one) also known as PZ51 was synthesized by Nattermann & Cie
However, starting with an SGLT2 inhibitor or a GLP-1 RA in an individual who is intolerant to metformin (primarily diarrhea) is a good choice, and even in the future we may see large diabetes organizations recommending these two classes as first line therapy once they get less expensive.
Xu MT, Zhang M, Wang GL, Gong S, Luo MJ, Zhang J, et al
Diabetes (2015) 64:31726.10.2337/db14-1514 46 KnaufCCaniPDPerrinCIglesiasMAMauryJFBernardEet alBrain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage
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