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Main outcome parameters and results: The main efficacy parameter was the effect of treatment on 6- and 12-month changes from baseline in nerve conduction velocity (NCV) and amplitude in the sensory (ulnar, sural and median) and motor (median, ulnar and peroneal) nerves
It works by mimicking a naturally occurring hormone, GLP-1, which is released by the gut after we eat and makes us feel full
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2Inject the water slowly down the inside wall of the peptide vial, avoiding foaming
1 How it works The design of orforglipron emphasizes stability in the GI tract, which allows oral dosing while preserving target engagement
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