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These adducts have been described in the extracellular media of GT overexpressing cells and the plasma of patients treated with oxaliplatin (Paolicchi et al., 2003
Moharamzadeh K, Brook IM, VanNoort R, Scutt AM, Thornhill MH
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The steady-state levels of COXII, a subunit of complex IV, was reduced, and the methylation of ADP/ATP translocase genes ANT1 and ANT2, as well as the electron transfer flavoprotein ETF, were found to be hypomethylated
Because several conditions that cause cold legs are also linked to cardiovascular, metabolic, or neurological health, persistent symptoms deserve careful evaluation rather than dismissal
