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Pal, Physical Chemistry Chemical Physics 16, (2014) 1818518197
YJ: Conceptualization, Validation, Investigation, Writing review and editing
Animal studies show no major adverse effects at therapeutic doses
Recent studies demonstrate that curcumin significantly downregulates miR-21 (oncomiR suppression) while upregulating miR-34a/b/c by two- to four-fold in colorectal cancer cells ( p = 0.002), miR-138 ( p = 0.024), and miR-16 ( p = 0.0001) in human subjects, demonstrating systemic miRNA modulation ( Resveratrol targets the miR-200 family and miR-125b-5p for epithelialmesenchymal transition (EMT) inhibition
GLP-1 analogue, exendin-4, modulates MAPKs activity but not the heat shock response in human HepG2 cells
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