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This is the earliest and most immediately perceptible effect
If the patient needs to transport the medication (e.g., traveling), it should be carried in a cooler bag with ice packs to maintain the cold chain
However, one common yet often overlooked reason for fatigue is a deficiency in vitamin B12
NNMT is overexpressed in adipose tissue of obese subjects, and its inhibition has been explored as a strategy to modulate methyl group flux and NAD+ precursor availability
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