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ACSL4 acylates AA, and subsequently, LPCAT3 catalyzes the acylated AA to membrane PL, which raises the oxidation of membrane-sensitive fatty acids such as PUFA, ultimately leading to lipid peroxidation [73]
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Glucose-6-phosphate dehydrogenase is found in all cells and is responsible for the first reaction of the pentose phosphate pathway in which glucose-6-phosphate is oxidized to 6-phosphogluconolactone with concomitant production of NADPH
As mentioned, glutathione injections work by delivering the antioxidant directly into the bloodstream
This high energy demand creates a byproduct of oxidative stress
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