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222 In a randomized controlled trial in elderly patients with mild cognitive impairment living in the United Kingdom, supplementing with 800 mcg folic acid, 500 mcg B 12 , and 20 mg B 6 daily for two years reduced atrophy of gray matter (brain tissue most vulnerable to Alzheimer pathology) up to seven-fold in those with baseline homocysteine levels higher than 11 mol/L

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It works by preventing NNMT from depleting methyl groups needed for optimal cellular function and by increasing NAD levelsan essential molecule for mitochondrial health and energy production

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