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People with severe gastrointestinal disease, including gastroparesis, may not tolerate semaglutide well since it slows gastric emptying
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Levothyroxine and medicines with narrow timing requirements deserve special attention
GIPR antagonist effects in mice global loss of Gipr or Glp-1r We next assessed the ability of a mouse GIPR neutralizing antibody 23 (Kb of 5 nmol l 1 , potency for antagonism of GIP-induced cAMP accumulation) to affect HFD-induced weight gain and food intake in lean mice kept at thermoneutrality (28 C), an environmental temperature where potential confounding effects due to differences in metabolic rate are lowest
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