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The Morning Inflammatory Peak Conversely, many people with chronic injuries feel the most pain and stiffness in the morning
No associations were observed for other brain volume measures (total brain, white matter and hippocampus), white matter hyperintensity volume or MRI markers of small vessel disease (fractional anisotropy and mean diffusivity)
In complex chronic conditions like Long COVID and ME/CFS, this initial acute depletion triggers a vicious, self-perpetuating cycle of cellular dysfunction
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Exposure to Certain Medications: Drugs that are folate antagonists, such as methotrexate (used in chemotherapy), can deplete CNS folate
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