In addition to their anti-inflammatory effects, these compounds have inhibitory effects on the following pathways: inflammasome (NLRP3), Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway, endothelial cell vascular cell adhesion molecule-1 (VCAM-1) or intercellular adhesion molecule-1 (ICAM-1), matrix metalloproteinases involved in remodelling and metastasis (MMP 2, MMP 9), and chronic cycloxogenase derived prostaglandins that promote angiogenesis and immunosuppression (182)
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Among other things, there is no guarantee that planned or ongoing studies will be completed as planned, that future study results will be consistent with study results to date, that orforglipron will prove to be a safe and effective treatment for type 2 diabetes, that orforglipron will receive regulatory approval, or that Lilly will execute its strategy as expected
Patty's Toxicology Volumes 1-9 5th ed