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Cancer incidence and mortality after treatment with folic acid and vitamin B12
Pro-Hyp, Hyp-Gly) act as signaling molecules that stimulate fibroblast activity and increase endogenous collagen synthesis Supports reductions in collagenase/gelatinase enzyme activity, which helps limit connective tissue breakdown and improves skin elasticity and hydration Best For: Skin elasticity/anti-aging support, joint pain and cartilage maintenance, and general connective tissue and tendon-ligament recovery Typical Protocol: 1 g/day has been used in trials for skin hydration and elasticity (RCT, PMC6073484), while 5-15 g/day is the range studied for joint health and muscle recovery, with 15 g/day showing greater benefit than 5 g/day (systematic review, PMC8521576)
In animal studies, it has been shown to reduce symptoms similar to arthritis, suggesting its potential to protect joints and improve mobility
Therefore, when you are deficient in B12, MMA levels increase in the blood and urine
For researchers drawing from a reconstituted vial over days or weeks, this protection is essential
