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Skin laxity is another concern with weight loss exceeding 15-20% of body weight
Pflipsen & Vega Colon (2020)
The February 2026 reclassification restored approximately 14 peptides to Category 1 status, meaning compounding pharmacies can legally prepare them again
100 percent subcutaneous | | Reported weight data | 12.4 % (36 mg, 72 wk, ATTAIN-1) | 24.2 % (12 mg, 48 wk, Phase 2) | | Food restriction | None | Not applicable | | Status | FDA-approved (Foundayo, April 2026) | Research substance, not approved | The table illustrates that the higher weight values of retatrutide result from a broader receptor activation and the injection-driven complete entry of the active substance, while orforglipron has its strength in ease of administration and oral availability
The carve-out applies to obesity coverage in most cases
